1988年北京农业大学生物学院获学士学位；1997年中国农业大学资源与环境学院获硕士学位；2002年比利时安特卫普大学生物系获博士学位；2003-2006年美国普度大学从事博士后研究；2006-2008年美国俄亥俄州立大学和加拿大不列颠哥伦比亚大学任研究助理。现任中国科学院植物研究所研究员，中国科学院大学岗位教授，中国细胞生物学学会理事，中国空间科学学会微重力科学与应用专业委员会委员，北京细胞生物学学会理事。迄今在Nature Communications, PNAS, Current Biology, Plant Cell, Molecular Plant, Development, Plant Physiology等国际知名学术期刊上发表研究论文40余篇。

主要研究工作：

以模式植物拟南芥、模式作物水稻和苜蓿为主要研究材料，开展植物生长发育中细胞分裂、分化和生长适应环境变化的分子调控机制。研究内容包括：

1. 植物细胞分裂和分化调控机制

以植物表皮气孔为主要研究体系，研究生长素、油菜素内酯、多肽等激素通过受体蛋白、转录因子和细胞周期蛋白调控气孔发生、发育和分布的调控途径，揭示植物器官发育中细胞分裂和分化的精细调控机制。

2. 细胞骨架和植物重力感重与响应机理

重力是影响植物生长和发育的重要地球环境因素之一，利用分子细胞生物学、力学交叉学科技术和方法，研究细胞骨架与植物感重细胞中“淀粉体-平衡石”运动的生物力学关系，揭示植物细胞感知重力和响应的作用机理。

3. 作物发育和抗逆途径

利用现代分子生物学技术，开展水稻和苜蓿耐旱、耐盐碱分子途径挖掘和功能基因解析，为创制耐逆新品种提供科学依据和材料。

主持和参加的科研项目：

中国科学院创新工程重要方向性研究项目；国家自然科学基金面上项目和国际合作交流项目；国家重点基础研究发展计划（973项目）；国家转基因专项；中国科学院战略性科技先导专项（A类）。

研究论文（注*为通讯作者，#为共同第一作者）：

2022

Leng YJ#, Yao YS#, Yang KZ#, Wu PX, Xia YX, Zuo CR, Luo JH, Wang P, Liu YY, Zhang XQ, Ye D, Le J, Chen LQ*. 2022. Arabidopsis ERdj3B coordinates with ERECTA-family receptor kinases to regulate ovule development and the heat stress response. Plant Cell, 34(10):3665-3684.

Yang Y, Liu F, Liu L, Zhu M, Yuan J, Mai YX, Zou JJ, Le J, Wang Y, Palme K, Li X, Wang Y, Wang L*. 2022. The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis. Journal of Integrative Plant Biology, 64(10):1916-1934.

Yang KZ#, Zuo CR#, Leng YJ, Yue JL, Liu HC, Fan ZB, Xue XY, Dong J, Chen LQ, Le J*. 2022. The functional specificity of ERECTA-family receptors in Arabidopsis stomatal development is ensured by molecular chaperones in the endoplasmic reticulum. Development, 149(17): dev200892.

Qu XX, Zou JJ, Wang JX, Yang KZ, Wang XQ*, Le J*. 2022. A rice R2R3-Type MYB transcription factor OsFLP positively regulates drought stress response via OsNAC. International Journal of Molecular Sciences, 23:5873.

Zhang CX, Zhang J, Liu HC, Qu XX, Wang JX, He QXM, Zou JJ, Yang KZ, Le J*. 2022. Transcriptomic analysis reveals the role of FOUR LIPS in response to salt stress in rice. Plant Molecular Biology, 110:37-52.

Wang L#, Li D#, Yang K#, Guo X, Bian C, Nishimura T, Le J, Morita MT, Bergmann DC, Dong J*. 2022. Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants. Nature Communications, 13: 7.

Li Y, Xue S, He Q, Wang J, Zhu L, Zou J, Zhang J, Zuo C, Fan Z, Yue J, Zhang C, Yang K, Le J*. 2022. Arabidopsis F-BOX STRESS INDUCED 4 is required to repress excessive divisions in stomatal development. Journal of Integrative Plant Biology, 64: 56-72.

2020

Yang KZ#,*, Wang L#, Le J, Dong J*. 2020. Cell polarity: Regulators and mechanisms in plants. Journal of Integrative Plant Biology, 62:132-147.

2019

Yang KZ, Zhu LL, Wang HZ, Jiang M, Xiao CW, Hu XY, Vanneste S, Dong J, Le J*. 2019. A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division. Proc. Natl. Acad. Sci. USA, 116: 18126-1813.

Qi SL#, Lin QF#, Feng XJ, Han HL, Liu J, Zhang L, Wu S, Le J*, Blumwald E, Hua X*. 2019. IDD16 negatively regulates stomatal initiation via trans-repression of SPCH in Arabidopsis. Plant Biotechnology Journal, 17:1446.

Xue S, Zou J, Liu Y, Wang M, Zhang C, Le J*. 2019. Involvement of BIG5 and BIG3 in BRI1 trafficking reveals diverse functions of BIG-subfamily ARF-GEFs in plan growth and gravitropism. International Journal of Molecular Sciences, 20:2339.

2018

Qu XX, Yan M, Zou JJ, Jiang M, Yang KZ, Le J*. 2018. A2-type cyclin is required for the asymmetric entry division in rice stomatal development. Journal of Experimental Botany, 69: 3587-3599.

2016

Zou JJ#, Zheng ZY#, Xue S, Li HH, Wang YR, Le J. 2016. Arabidopsis Actin-Related Protein3 functions in amyloplast sedimentation and polar auxin transport in root gravitropism. Journal of Experimental Botany, 67: 5325-5337 

2015

Wang HZ, Yang KZ, Zou JJ, Xie ZD, Morita M, Tasaka M, Friml J, Grotewold E, Beeckman T, Vanneste S, Sack F, Le J*. 2015 Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism. Nature Communications, 6:8822, doi: 10.1038/ncomms9822. 

Chen Q, Liu Y, Maere S, Lee EK, Van Isterdael G, Xie ZD, Xuan W, Lucas J, Vassileva V, Kitakura S, Marhav P, Wabnik K, Geldner N, Benkov E, Le J, Fukaki H, Grotewold E, Li CY, Friml J, Sack F, Beeckman T, Vanneste S. 2015 A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development. Nature Communications, 6:8821 doi: 10.1038/ncomms9821. 

Zheng HQ, Han F, Le J. 2015. Higher plants in space: Microgravity perception, response, and adaptation. Microgravity Science and Technology, 6: 377-386. 

Zheng ZY#, Zou JJ#, Li HH, Xue S, Wang YR, Le J*. 2015. Microrheological insights into the dynamics of amyloplasts in root gravity-sensing cells. Molecular Plant, 8: 660-663. 

Yang KZ, Jiang M, Wang M, Xue S, Zhu LL, Wang HZ, Zou JJ, Lee E, Sack F, Le J*. 2015. Phosphorylation of serine 186 of bHLH transcription factor SPEECHLESS promotes stomatal development in Arabidopsis. Molecular Plant, 8: 783-795. 

Wang M, Yang KZ, Le J*. 2015. Organ-specific effects of brassinosteroids on stomatal production coordinate with the action of too many mouths. Journal of Integrative Plant Biology, 57: 247-255. 

程巧, 乐捷*,曾建国*.2015.药用植物博落回形态与发育解剖学研究。植物学报, 50:72-82

2014

Yang KZ, Wang HZ, Shan X, Qu XX, Zou JJ and Le J*. 2014. Requirement of A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis. Journal of Experimental Botany, 65: 2449-2461. 

Yang KZ, Jiang M, Le J*. 2014. A new loss-of-function allele 28y reveals a role of ARGONAUTE1 in limiting asymmetric division of stomatal lineage ground cell. Journal of Integrative Plant Biology, 56: 539-549. 

Le J*, Liu XG, Yang KZ, Chen XL, Zou JJ, Wang HZ, Wang M, Vanneste S, Morita M, Tasaka M, Ding ZJ, Friml J, Beeckman T and Sack F*. 2014. Auxin transport and activity regulate stomatal patterning and development. Nature Communications, 5: 3090 doi: 10.1038/ncomms4090.

Le J*, Zou J, Yang K and Wang M. 2014. Signaling to stomatal initiation and cell division. Frontiers in Plant Science, 5:297. 

程巧, 曾建国*, 乐捷*.2014.异喹啉类生物碱生物合成、运输、储藏相关细胞生物学研究进展。植物学报, 49:720-728

2010年及以前

Kotchoni SO, Zakharova T, Mallery E, Le J, El-Assal S, Szymanski D .2009. The association of the Arabidopsis actin-related protein (ARP) 2/3 complex with cell membranes is linked to its assembly status, but not its activation. Plant Physiology 151：2095–2109 

Basu D, Le J, Zakharova T, Mallery E, Szymanski D .2008. A SPIKE1 signaling complex controls actin-dependent cell morphogenesis through the heteromeric WAVE and ARP2/3 complexes. PNAS 105:4044-4049 

Le J, Mallery E, Zhang C, Brankle S, Szymanski D .2006. Arabidopsis BRICK1 is an essential subunit of the WAVE complex that selectively stabilizes the Arp2/3 activator SCAR2. Current Biology 16: 895-901 

Basu D#, Le J#, El-Essal S, Huang S, Zhang C, Mallery E, Koliantz G, Staiger C, Szymanski D .2005. DISTORTED3/SCAR2 is a putative Arabidopsis WAVE complex subunit that activates Arp2/3 and is required for epidermal morphogenesis. Plant Cell 17: 502-524 

El-Assal S, Le J, Basu D, Mallery E, Szymanski D .2004. DISTORTED2 encodes an ARPC2 subunit of the putative Arabidopsis ARP2/3 complex. Plant J 38: 526-538 (cover photograph) 

El-Assal S#, Le J#, Basu D, Mallery E, Szymanski D .2004.Arabidopsis GNARLED encodes a NAP125 homologue that positively regulates ARP2/3. Current Biology 14: 1045-1049 

Basu D, El-Assal S, Le J, Mallery E, Szymanski D .2004. Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development. Development 131: 4345-4355 

Le J, El-Assal S, Basu D, Saad M, Szymanski D .2003. Requirements for Arabidopsis ATARP3 and ATARPP3 during epidermal development. Current Biology 13: 1341-1347 

Verbelen J-P, De Cnodder T, Le J, Vissenberg K, Baluska F .2006. The root apex of Arabidopsis thaliana consists of four distinct zones of growth activities. Plant Signaling & Behavior 1: 6 

Le J, Vandenbussche F, De Cnodder T, Van Der Straeten D, Verbelen J-P .2005. Cell elongation and microtubule behaviour in the Arabidopsis hypocotyl: responses to ethylene and auxin. Journal of Plant Growth Regulation 24: 166-178 

Smets R#, Le J#, Prinsen E, Verbelen J-P, Van Onckelen HA .2005. Cytokinin-induced hypocotyl elongation in light-grown Arabidopsis plants with inhibited ethylene action or indole-3-acetic acid transport. Planta 221: 39-47 

Le J, Vandenbussche F, Van Der Straeten D, Verbelen J-P .2004. Position and cell type dependent microtubule reorientation characterizes the early response of the Arabidopsis root epidermis to ethylene. Physiologia Plantarum 121: 513-519 

Vandenbussche F, Smalle J, Le J, et al. 2003.The Arabidopsis mutant alh1 illustrates a cross talk between ethylene and auxin. Plant Physiology 131: 1228-1238 

Verbelen J-P, Le J, Vissenberg K .2003.The cytoskeleton, elongation and the control of elongation. Cell Biology International 27: 287-289 

Le J, Vandenbussche F, Van Der Straeten D, Verbelen J-P .2001. In the early response of Arabidopsis roots to ethylene, cell elongation is up- and down regulated and uncoupled from differentiation. Plant Physiology 125: 519-522 

Van Gestel K, Le J, Verbelen J-P .2001. A comparison of F-actin labeling methods for light microscopy in different plant specimens: multiple techniques supplement each other. Micron 32: 571-578 

Verbelen J-P, Vissenberg K, Kerstens S, Le J .2001. Cell expansion in the epidermis: microtubules, cellulose orientation and wall loosening enzymes. J Plant Physiology 158: 537-543 

Le J, Wang Z, Zhang FS .1997. Effects of boron-deficiency on growth of cucumber seedlings as affected by low temperature and illumination. Plant Nutrition and Fertilizer Sciences 3: 42-51 (in Chinese with English Abstract) 

Wang X, Le J et al. 1993. Experimental investigation of RDI on high-density peach orchard. J Beijing Agri. Sci, Vol 6 (in Chinese) 

Le J, Shi S .1992. Comparison of using efficiencies of several fertilizers in adjustment nutrition disorder on apple trees. J Beijing Agri Sci, supp. (in Chinese) 

著作专著：

1.杨克珍，乐捷. 2015. 细胞分化：植物细胞分化与器官发生，许智宏, 种康 主编，科学出版社

2.邹俊杰，朱生伟，乐捷. 2015. 表皮毛发育：植物细胞分化与器官发生，许智宏, 种康 主编，科学出版社

3. Verbelen J-P, Le J, Vissenberg K, De Cnodder T, Vandenbussche F, Sugimoto K, Van Der Straeten D. 2005.  Microtubules and the control of cell elongation in Arabidopsis roots. In: The Plant Cytoskeleton: Functional Diversity and Biotechnological Implications (NATO Monograph), Eds: Y Blume, A Yemets, C Lloyd, IOS Press, Amsterdam, The Netherlands

4. Le J. 1994. Monitoring the leaching of nitrogen fertilizer caused by irrigation. In: Development of Orchard Management Practices of Efficient Irrigation and Maximum Yield Research and Development Program, Zeng Dechao & P.H. Jerie ed, (Beijing, Beijing Agri. University Press, in Chinese with English Abstract)

5.Le J. 1994. Introduction to soil parameters measurement. In: Management Practice Guide to RDI-HD Orchard, Zeng Dechao & P. H. Jerie ed (Beijing, Beijing Agri. University Press, in Chinese with English Abstract)