
| 姓 名: | 王雷 |
|---|---|
| 职务/职称: | 研究员、研究组组长 |
| 联系电话: | (86)-010-62836175 |
| 电子邮件: | wanglei@ibcas.ac.cn |
| 个人网页: | http://www.klpmp.ibcas.ac.cn/kydw/xbfhyqgfs/wl/202101/t20210108_611996.html |
| 研 究 组: | 植物生物钟与发育调控研究组 |
| 王雷,男,博士,研究员,博士生导师。 |
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1999年于东北师范大学获学士学位;2002年于吉林农业大学获硕士学位;2006年在中国科学院植物研究所获得博士学位。2006-2013年,在美国俄亥俄州立大学分子遗传学系从事博士后研究。2010年3月-2010年9月,在韩国浦项科技大学作访问学者。2013年11月到植物所工作,入选国家人才计划。 现任中国科学院西安分院副院长、党组成员、中国科学院大学岗位教授、中国细胞生物学学会生物节律分会副主委、中国植物学会常务理事、以及《植物学报》主编、Plant Cell and Environment副主编、Crop Journal和Seed Biology编委。在PNAS,Plant Cell,Developmental Cell, EMBO Journal,Nature Communications,Nucleic Acids Research,Cell Reports,Molecular Plant等期刊发表论文50余篇。参与申报中国发明专利18项,其中已授权14项。参与国际专著编写2部。 生物钟分子系统(Circadian molecular system)是生物体为了因应地球自转而产生的昼夜环境周期性的变化,从而进化出的协调细胞内基因表达,及代谢网络调控的分子系统。我们课题组以水稻、苜蓿和拟南芥等为主要研究对象,解析植物生物钟分子系统组成、及其对植物生长发育和非生物胁迫适应性的调控机理,主要包括对开花时间调控、耐盐碱调控等方面的分子机理研究。研究核心主要是围绕植物生物钟分子系统如何通过对环境信号的整合而实现对输出系统的控制,以期为提高农作物品质与产量提供时间生物学方面的理论依据和遗传资源。课题组主要研究方向为: 1)植物生物钟分子系统的组成解析及关键因子的多维度调控; 2)水稻生物钟分子系统的表观遗传调控机制; 3)生物钟协同调控水稻发育和盐碱耐受的遗传网络。 主要主持的科研项目: 1. “主粮作物生长发育与盐碱胁迫响应平衡调控机制”(2023.12-2028.11), 国家重点研发计划,项目负责人 2. “蓝光光周期加速水稻抽穗期的分子机制”(2025.1-2028.12), 国家基金委重点项目,项目负责人 3. “PRR9蛋白街道高温信号调控生物钟周期的机制研究”(2024.1-2027.12), 国家基金委面上项目,项目负责人 4. “生物钟关键转录因子OsPRR73调控水稻耐盐性的分子机制研究”(20218.1-2021.12), 国家基金委面上项目,项目负责人 研究论文(*标记为通讯作者) 2026 Su C, Niu YF, Yu YJ, Wang Y, He YQ, Wang L*. 2026. The circadian morning complex modulates abscisic acid signaling by transcriptionally repressing PYL4, PYL5, and PYL6 at dawn. Plant and Cell Physiology, https://doi.org/10.1093/pcp/pcag044 He YQ, Wang XL, Su C, Niu YF, Qin YM, Zhang JS, Wang L*. 2026. A thermoregulatory module for timekeeping in Arabidopsis. Developmental Cell, doi: 10.1016/j.devcel.2026.07.011 2025 Su C, Qin YM, Yu YJ, Wang Y, He YQ, Davis S*, Wang L*. 2025. A circadian morning complex modulates far-red light signaling in Arabidopsis. Nature Communications, 16: 9328. https://doi.org/10.1038/s41467-025-65242-9 Zhang YY*, Wang L*. 2025. Advances in basic biology of alfalfa (Medicago sativa L): a comprehensive overview. Horticulture Research, 12: uhaf081. https://doi.org/10.1093/hr/uhaf081 Zhang YY, Zhao HJ, Xiang HX, Zhang JS, Wang L*. 2025. Seasonal and diurnal transcriptome atlas in natural environment reveals flowering time regulatory network in alfalfa. Plant Cell & Environment, 48:4723-4739. https://doi.org/10.1111/pce.15466 2024 Zuo Y#, Liu HB#, Li B#, Zhao H, Li XL, Chen JT, Wang L, Zheng QB, He YQ, Zhang JS, Wang MX, Liang CZ, Wang L*. 2024. The Idesia polycarpa genome provides insights into its evolution and oil biosynthesis. Cell Reports, 43(3): 113909. https://doi.org/10.1016/j.celrep.2024.113909 Liu H#, Zhao H#, Zhang Y#, Li X#, Zuo Y#, Wu Z, Jin K, Xian W, Wang W, Ning W, Liu Z, Zhao X, Wang L, Sage RF, Lu T, Stata M*, Cheng SF*. 2024. The genome of Eleocharis vivipara elucidates the genetics of C3–C4 photosynthetic plasticity and karyotype evolution in the Cyperaceae. Journal of Integrative Plant Biology, 66: 2505–2527. https://doi.org/10.1111/jipb.13765 Chawla S, Oster H, Duffield GE, Maronde E, Guido ME, Chabot C, Dkhissi-Benyahya O, Provencio I, Goel N, Youngstedt SD, Zi Ching Mak N, Caba M, Nikhat A, Chakrabarti S, Wang L, Davis SJ*. 2024. Reflections on several landmark advances in circadian biology. Journal of Circadian Rhythms, 22(1): 1–11. https://doi.org/10.5334/jcr.236 2023 Yu YJ, Su C, He YQ, Wang L*, 2023. B-Box proteins BBX28 and BBX29 interplay with PSEUDO-RESPONSE REGULATORS to fine-tune circadian clock in Arabidopsis. Plant Cell & Environment,https://doi.org/10.1111/pce.14648 Xu H, Wang X, Wei J, Zuo Y, Wang L*, 2023. The Regulatory Networks of the Circadian Clock Involved in Plant Adaptation and Crop Yield. Plants, 12(9): 1897. https://doi: 10.3390/plants12091897 2022 He YQ, Yu YJ, Wang XL, Qin YM, Su C, Wang L*. 2022. Aschoff’s rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9. Nature Communications, 13:5869. Wang Y#, Su C#, Yu YJ#, He YQ, Wei H, Li N, Li H, Duan J, Li B, Li JG, Davis S, Wang L*. 2022. TIME FOR COFFEE regulates phytochrome A-mediated hypocotyl growth through dawn-phased signaling. ThePlant Cell, 34:2907-2924. Wei H, Xu H, Su C, Wang XL, Wang L*. 2022. Rice CIRCADIAN CLOCK ASSOCIATED 1 transcriptionally regulates ABA signaling to confer multiple abiotic stress tolerance. Plant Physiology, 190:1057-1073. Ronald J, Su C, Wang L, Davis SJ*. 2022. Cellular localization of Arabidopsis EARLY FLOWERING3 is responsive to light quality. Plant Physiology,190:1024–1036. 2021 Wei H, Wang XL, He YQ, Xu H, Wang L*. 2021. Clock component OsPRR73 positively regulates ricesalt tolerance by modulating OsHKT2;1-mediated sodium homeostasis. The EMBO Journal, 40: e105086. Yuan L#, Yu YJ#, Liu MM, Song Y, Li HM, Sun JQ, Wang Q, XieQG*, Wang L*, Xu XD*. 2021. BBX19 fine-tunes the circadian rhythm by interactingwith PSEUDO-RESPONSE REGULATOR proteins tofacilitate their repressive effect on morning-phasedclock genes. The Plant Cell, 33(8): 2602-2617. Tian WW#, Wang RY#, Bo CP, Yu YJ, Zhang YY, Shin GI, Kim WY, Wang L*.2021.SDC mediates DNA methylation-controlled clock paceby interacting with ZTL in Arabidopsis. Nucleic Acids Research, 49(7):3764-3780. Wang XL#, He YQ#, Wei H, Wang L*. 2021. A clock regulatory module is required for salt tolerance and control of heading date in rice. Plant Cell Environment, 44:3283-3301. (cover story). Zhang YY, Li N, Wang L*. 2021.Phytochrome interacting factor proteins regulate cytokinesis in Arabidopsis. Cell Reports, 35:109095. Li N, Bo CP, Zhang YY*, Wang L*.2021. PHYTOCHROME INTERACTING FACTORS PIF4 and PIF5 promote heat stress induced leaf senescence in Arabidopsis. Journal of Experimental Botany, 72(12):4577-4589. Su C, Wang Y, Yu YJ, He YQ, Wang L*.2021.Coordinative regulation of plants growth and development by light and circadian clock.aBIOTECH, 2:176–189. 2020 Wei H, Wang XL, Xu H, Wang L*. 2020. Molecular basis of heading date control in rice. aBIOTECH, 1:219-232. Li N#, Zhang YY#, He YQ, Wang Y, Wang L*. 2020. Pseudo Response Regulators regulate photoperiodic hypocotyl growth by repressing PIF4/5 transcription. Plant Physiology, 183(2): 686-699. Wang Y, He YQ, Su C, Zentella R, Sun TP, Wang L*. 2020. Nuclear localized O-fucosyltransferase SPY facilitates PRR5 proteolysis to fine-tune the pace of Arabidopsis circadian clock. Molecular Plant, 3: 446-458. (cover story). Wang Y#, Qin YM#, Li B, Zhang YY, Wang L*. 2020. Attenuated TOR signaling lengthens circadian period in Arabidopsis. Plant Signaling & Behavior, 2: e1710935. Kim TS, Wang L, Kim YJ, Somers DE*. 2020. Compensatory mutations in GI and ZTL may modulate temperature compensation in the circadian clock. Plant Physiology, 2: 1130-1141. 2019 Zhang YY, Bo CP, Wang L*. 2019. Novel crosstalks between circadian clock and jasmonic acid pathway finely coordinate the tradeoff among plant growth, senescence and defense. International Journal of Molecular Sciences, 20: 5254. Li B#, Wang Y#, Zhang YY, Tian WW, Chong K, Jang JC, Wang L*. 2019. PRR5, 7 and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis. Nucleic Acids Research, 10: 5001-5015. 2018 Zhang YY, Wang Y, Wei H, Li N, Tian WW, Chong K, Wang L*. 2018. Circadian evening complex represses jasmonate-induced leaf senescence in Arabidopsis. Molecular Plant, 11, 326-337. (cover story). Wang Y, Zhang YY, Wang L*. 2018, Cross regulatory network between circadian clock and leaf senescence is emerging in higher plants. Frontiers in Plant Science, 9: 700. 魏华, 王岩, 刘宝辉, 王雷. 2018. 植物生物钟及其调控生长发育的研究进展. 植物学报, 53: 456-467. 2017 Cha JY, Kim J, Kim TS, ZengQN, Wang L, Lee SY, Kim WY, Somers DE*.2017. GIGANTEA acts as a co-chaperone with HSP90 to facilitate maturation of the client protein ZEITLUPE in the Arabidopsis circadian clock. Nature Communications, 8: 3. 2016 Wang L, Chong K. 2016. The essential role of cytokin in signaling in root apical meristem formation during somatic embryogenesis. Frontiers in Plant Science, 6: 1196-1200. 2015及以前 JiaYB, TianHY, Li HJ, Yu QQ, Wang L, Friml J, Ding ZJ. 2015. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. Journal of Experimental Botany, 4631-4642. Choudhary M, Nomura Y, Wang L, Nakagami H, Somers DE. 2015. Quantitative circadian phosphoproteomic analysis of Arabidopsis reveals extensive clock control of key components in physiological, metabolic, and signaling pathways. Molecular & Cellular Proteomics, 14: 2243-2260. Wang L, Kim J and Somers D*. 2013. Transcriptional corepressor TOPLESS comlexes with pseudoresponse regulator proteins and histone deacetylase to regulate circadian transcription. Proc. Natl. Acad. Sci. USA, 110(2):761-766. Kim Y, Lim J, Yeom M, Kim H, Kim J, Wang L, Somers D and Nam H*. 2013. ELF4 regulates GIGANTEA chromatin access through subnuclear sequestration. Cell Reports, 3:671-677. Zhang C, XuYY, GuoSY, Zhu JY, Huan Q, Liu HH, Wang L, LuoGZ, Wang XJ and Chong K*. 2012. Dynamics of brassinosteroid response modulated by negative regulator LIC in rice. PLoS Genetics, 8(4): e1002686. Wang L and Chong K*. 2010. Auxinbrassinosteroids and G protein signaling. In Integrated G protein Signaling in Plants. Series of Signaling and Communication in Plants. page: 135-154 (Book chapter). Wang L, Fujiwara S and Somers D*. 2010. PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock. The EMBO Journal, 29(11):1903-1915. Li D, Wang L, Wang M, Xu Y, Luo W, Liu Y, Xu Z, Li J and Chong K*. 2009. Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield. Plant Biotechnology Journal, 7:791–806. Wang L, Xu Y, Zhang C Ma QB, Kim J, XuZH and Chong K*. 2008. OsLIC, a novel CCCH-type zinc finger protein with transcription activation, mediates rice architecture via brassinosteroids signaling. PLoS One. 3(10):e3521. Fujiwara S, Wang L, Han L, Suh SS, Salomé P, McClung R and Somers D*. 2008. Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins. Journal of Biological Chemistry, 283(34):23073-83. (Co-first author, cover story). Wang L, XuYY, Li J, Powell R, XuZH and Chong K*. 2007. Transgenic rice plants ectopically expressing AtBAK1 are semi-dwarfed and hypersensitive to 24-epibrassinolide. Journal of Plant Physiology, 164 (5):655-64. Liu KM, Wang L, Xu YY, Chen N, Ma QB, Li F and Chong K*. 2007. Overexpression of OsCOIN, a putative cold inducible zinc finger protein, increased tolerance to chilling, salt and drought, and enhanced proline level in rice. Planta, 226(4):1007-16. Wang L, XuYY, Ma QB, Li D, Xu ZH and Chong K*. 2006. Heterotrimeric G protein alpha subunit is involved in rice brassinosteroid response. Cell Research, 16(12):916-922. Wang ZY*, Wang QM, Chong K, Wang FR, Wang L, Bai MY and Jia CG. 2006. The brassinosteroid signal transduction pathway. Cell Research, 16(5): 427-34. 发明专利 1. OsMTA3基因在调控植物干旱胁迫响应中的应用,中国,2026,ZL202610219852.2 2. OsBBX24基因在水稻抽穗期调控中的应用,中国,2026,ZL.202610219490.7 3. 一种OsEra2基因及其培育调控水稻开花期的方法,中国,2025,ZL. 202510353464.9 4. 水稻OsRVED基因在调控水稻耐盐胁迫中的应用,中国,2025,ZL. 202511334277.2 5. 一种水稻盐胁迫调控基因OsMTA1及其应用,中国,2025,ZL202511343890.0 6. 一种山桐子果实含油率调控基因IpNF-YC2及其应用,中国,2025,ZL. 202511518804.5 7. 水稻盐胁迫调控基因OsEra1及其应用,中国,2024,ZL. 2024102254491.1 8. 一种用于鉴定山桐子含油率的InDel 分子标记及其应用,中国,2024,ZL. 202410176832.2 9. 山桐子U6 启动子及其应用,中国,2024,ZL. 202410176834.1 10. 一种用于快速精准鉴定苗期山桐子性别的CAPS分子标记及其应用,中国,2024,ZL. 202410233787.X 11. 植物含油率相关蛋白及其相关生物材料与应用,中国,2023,ZL. 202310964914.9 12. 调控水稻非生物胁迫耐受性相关的蛋白及其相关生物材料与应用,中国,2021,ZL.202111672574.X 13. 植物耐盐性相关蛋白及其相关生物材料与应用,中国,2020,ZL.202010546983.4 14. 调控植物耐盐性的方法及耐盐相关蛋白,中国,2020,ZL.202010546971.1 |