2004年在山东大学获得学士学位，2010年在北京大学获得博士学位。2010年到2018年先后在丹麦奥胡斯大学和丹麦哥本哈根大学进行博士后工作，其中2016年9月到2018年5月在美国加州大学洛杉矶分校（UCLA）进行访问学习。2018年7月起在丹麦哥本哈根大学担任助理教授，2024年1月到中国科学院植物研究所植物多样性与特色经济作物重点实验室工作。在Nature，Nature Communications，PLOS Biology，Nucleic Acids Research等刊物发表论文30余篇。
主要研究工作：
科学研究方面主要聚焦膜蛋白的结构与功能研究，使用生物物理，生物化学等手段研究跨膜转运蛋白的机制，从而理解物质跨膜运输和平衡的调控机理。
技术方面致力于发展冷冻电镜研究相关的技术手段，以扩大冷冻电镜技术在不同生物体系特别是植物体系内的应用范围并开辟新的研究思路。
现阶段主要关注的方向有：
1.植物特有代谢产物相关转运蛋白的结构和功能。
2.叶绿体跨膜转运蛋白的结构和功能。
3.发展以植物材料为来源进行结构生物学研究的通用技术平台
研究论文（注#为共同通讯作者，*为共同第一作者）
2024
Augestad E#, Olesen C, Grønberg C, Soerensen A, Velázquez-Moctezuma R, Fanalista M , Bukh J, Wang KT#, Gourdon P#,Prentoe J#, The hepatitis C virus envelope protein complex is a homodimer of heterodimers;Nature, manuscript accepted
Vidal-Calvo E#, Martin-Salazar A, Choudhary S, Dagil Ro, Raghavan SSR, Duvnjak L, Nordmaj MA, Clausen T , Skafte A, Oberkofler J,Wang KT, Agerbaek MeØ, Løppke C, Jørgensen AM, Ropac Daria, Mujollari J, Willis S, López AG, Miller RL, Karlsson RTG, Goerdeler F, Chen YH, Colaço AR, Wang Y, Lavstsen T, Martowicz A, Nelepcu I, Marzban M, Oo HZ, Ørum-Madsen MS1, Wang YZ, Nielsen MA, Clausen H, Wierer M, Wolf D , Gögenur I, Theander TG , Nakouzi NA, Gustavsson T, Daugaard M# and Salanti A#, Oncofetal chondroitin sulfate specific antibodies for tumor-agnostic cancer therapy; Nature Communications, manuscript accepted
Ye J, Chen H, Wang KT, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B#, Li W#, Structural insights into vesicular monoamine storage and drug interactions; Nature, 2024, 629(8010):235-243
Guo ZX, Orädd F, Bågenholm V, Grønberg C, Ma JF, Ott P, Wang Y, Andersson M, Pedersen PA, Wang KT# & Gourdon P#, Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases; Nature Communications,2024, 15(1):2690.
2023
Raghavan SSR, Turner L, Jensen RW, Johansen NT, Jensen DS, Gourdon P, Zhang J, Wang Y, Theander TG, Wang KT#, Lavstsen T#, Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1; Structure,2023, 31(10):1174-1183
Kang JS, Zhou X, Liu YT, Wang KT, Zhou ZH, Theoretical framework and experimental solution for the air-water interface adsorption problem in cryoEM; Biophysics Reports,2023,9(4):215-229
Couston J, Guo Z, Wang KT, Gourdon P, Blaise M, Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs; Curr Res Struct Biol., 2023, 8(6):100109
2022
Raghavan SSR, Dagil R, Lopez-Perez M, Conrad J, Bassi MR, Quintana MDP, Choudhary S, Gustavsson T, Wang Y, Gourdon P, Ofori MF, Christensen SB, Minja DTR, Schmiegelow C, Nielsen MA, Barfod L, Hviid L, Salanti A, Lavstsen T#, Wang KT#,Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA; PLOS Pathogens, 2022, 18(11): e1010924
Li P, Hendricks AL, Wang Y, Villones RLE, Lindkvist-Petersson K, Meloni G, Cowan JA, Wang KT#, Gourdon P#,Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria;Nature Communications,2022, 13(1): 4339
Song Y, Dai B, Wang Y, Wang Y, Liu C, Gourdon P, Liu L#, Wang KT#, Dong MD#, Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation;Nano Letters,2022,22(9): 3707-3712
Zhang L, Simonsen C, Zimova L, Wang KT, Moparthi L, Gaudet R, Ekoff M, Nilsson G, Hellmich UA, Vlachova V, Gourdon P#, Zygmunt PM#, Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function; Nature Communications,2022, 13(1): 7483
Li P, Nayeri N, Górecki K, Becares ER, Wang KT, Mahato DR, Andersson M, Abeyrathna SS, Lindkvist-Petersson K, Meloni G, Missel JW, Gourdon P#,. PcoB is a defense outer membrane protein that facilitates cellular uptake of copper;Protein Science,2022, 31(7): p.e4364
Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang KT, Andersson M, Meloni G, Gourdon P#. Structural basis of ion uptake in copper-transporting P1B-type ATPases;Nature Communications,2022, 13(1): 5121
Zhang L, Wang KT, Ning S, Pedersen PA, Duelli AS, Gourdon P, Isolation and Crystallization of the D156C Form of Optogenetic ChR2;Cells,2022, 11(5):895
2021
Wang KT*, Dagil R*, Lavstsen T, Misra SK, Spliid CB, Wang Y, Gustavsson T, Sandoval DR, Vidal-Calvo EE, Choudhary S, Agerbaek MØ, Lindorff-Larsen K, Nielsen MA, Theander TG, Sharp JS, Clausen TM, Gourdon P#, Salanti A#,Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding; Nature Communication,2021, 12(1): 2956
Li P*, Wang KT*, Salustros N, Grønberg C, Gourdon P#,Structure and transport mechanism of P5B-ATPases;Nature Communications,2021, 12(1):3973
Grønberg C, Hu Q, Mahato DR, Longhin E, Salustros N, Duelli A, Lyu P, Bågenholm V, Eriksson J, Rao KU, Henderson DI, Meloni G, Andersson M, Croll T, Godaly G, Wang KT, Gourdon P#, Structure and ion-release mechanism of PIB-4-type ATPases. Elife,2021, 10. e73124
2016-2020
Bucholc K, Aik WS, Yang XC, Wang KT, Zhou ZH, Dadlez M, Marzluff WF, Tong L#, Dominski Z#. Composition and processing activity of a semi-recombinant holo U7 snRNP; Nucleic Acids Research, 2020,48(3): 1508–1530
Wang KT*, Preisler SS*, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH#, Gourdon P#. Structure of the human ClC-1 chloride channel; PLOS Biology, 2019, 17(4): e3000218
Zhang L, Wang KT, Klaerke DA, Calloe K, Lowrey L, Pedersen PA, Gourdon P#, Gotfryd K#, Purification of Functional Human TRP Channels Recombinantly Produced in Yeast. Purification of Functional Human TRP Channels Recombinantly Produced in Yeast; Cells, 2019, 8(2): 148
Gotfryd K, Mósca AF, Missel JW, Truelsen SF, Wang KT, Spulber M, Krabbe S, Hélix-Nielsen C, Laforenza U, Soveral G, Pedersen PA#, Gourdon P#, Human adipose glycerol flux is regulated by a pH gate in AQP10;Nature Communications, 2018, 9(1): 4749
2015及以前
Sitsel O, Grønberg C, Autzen HE, Wang KT, Meloni G, Nissen P, Gourdon P#,. Structure and function of Cu (I)-and Zn (II)-ATPases; Biochemistry, 2015, 54(37): 5673-5683
Bublitz M, Nass K, Drachmann ND, Markvardsen AJ, Gutmann MJ, Barends TR, Mattle D, Shoeman RL, Doak RB, Boutet S, Messerschmidt M, Seibert MM, Williams GJ, Foucar L, Reinhard L, Sitsel O, Gregersen JL, Clausen JD, Boesen T, Gotfryd K, Wang KT, Olesen C, Møller JV, Nissen P. Structural studies of P-type ATPase–ligand complexes using an X-ray free-electron laser.IUCrJ,2015, 2(4): 409-420
Wang KT*, Sitsel O*, Meloni G, Autzen HE, Andersson M, Klymchuk T, Nielsen AM, Rees DC, Nissen P#, Gourdon P#,Structure and mechanism of Zn2+-transporting P-type ATPases; Nature, 2014, 514(7523): 518-522
Wang KT*, Desmolaize B, Nan J, Zhang XW, Li LF, Douthwaite S#, Su XD#,Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA; Nucleic Acids Research, 2012,40(11): 5138–5148
Cao YL, Li GL, Wang KT, Zhang HY, Li LF. Crystallization and preliminary X-ray analysis of argininosuccinate lyase from Streptococcus mutans;Acta Crystallographica Section F, 2011, 67(6): 682-684
Wang KT*, Ma L, Nan J, Su XD, Li L#,Purification, crystallization and preliminary X-ray crystallographic analysis of 23S RNA m2G2445 methyltransferase RlmL from Escherichia coli;Acta Crystallographica Section F. 2010, 66(11): 1484-1486
Wang XJ, Cao Q, Liu X, Wang KT, Mi W, Zhang Y, Li LF, LeBlanc AC, Su XD. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation; EMBO Reports, 2010, 11(11): 841-847
Wang KT*, Wang J*, Li LF, Su XD#,Crystal structures of catalytic intermediates of human selenophosphate synthetase 1; Journal of Molecular Biology. 2009, 390(4): 747-759
Wang KT*, Li LF, Zhang XY, Liang YH, Wei SC and Su XD#. Preparation, Crystallization and Preliminary X-ray Crystallographic Analysis of Smu.776 From Caries Pathogen Streptococcus mutans; Prog. Biochem. Biophys.2007, 34(2): 176-179
