漆小泉，中国科学院植物研究所研究员，博士生导师。中国科学院人才计划入选者，享受国务院政府特殊津贴专家。1984年获华中农业大学学士学位，1990年获英国伯明翰大学获硕士学位，1994-1998年在荷兰瓦根宁根大学学习，获博士学位。1998年至2006年在英国John Innes Center从事博士后研究，后期任高级研究助理。主要从事植物发育和代谢生物学研究，迄今在Nat Commun、Nat Chem Biol、Annu Rev Phytopathol、PNAS、Plant Cell、Mol Plant等SCI期刊发表研究论文70余篇，被引用3400余次。出版《植物代谢组学—方法与应用》中英文专著各1部。获授权中国专利18项，申请国际专利（PCT）2项。任国际萜类代谢（Terpnet 2017）第13届执行委员会主席；国际细胞色素P450多样性及生物技术大会第13 - 15届（2020）学术委员会委员；中国植物学会第一届监事会监事，中国植物生理与分子生物学学会和中国生物物理学会代谢组学分会理事；担任Front Plant Sci和植物学报杂志副主编及Plant Biotechnol J和Theor Appl Genet等编委。

主要研究工作: 

1.植物代谢物的合成及其功能研究 

植物合成并积累种类繁多的代谢物。这些代谢物在植物的生长发育、环境适应中发挥着重要作用；一些特殊的代谢物是重要药物和人体必需的重要营养成分。我们以水稻、丹参等为主要研究材料，采用分子生物学以及包括代谢组学在内的分子系统生物分析方法系统地解析植物萜类及其它代谢物的生物合成途径及其调控机理，重点揭示代谢物和及其合成途径的生物学功能。 

2.植物代谢组学及其应用 

植物合成的代谢物有20万至100万种之多，且结构与理化性质差异很大，从而使植物的代谢组学研究更具挑战性。我们使用先进的分析仪器，结合现代组学和系统生物的数据分析手段，进行植物代谢物的定性和定量分析；探索代谢组学在揭示植物科学、农业生产和环境安全等领域的应用前景。 

3.植物持久抗病性的分子机制研究 

作物的持久抗病性在农业生产中具有重要的应用价值，如，小麦条锈病在我国小麦主产区发病严重，危害小麦产量。然而小麦的基因组庞大、复杂，严重阻碍了其功能基因组学的研究。我们利用基因组较小、具有全基因组序列的二穗短柄草为模式植物，解析麦类作物与麦类锈菌的互作机制，为麦类作物的持久抗病品种培育和农业可持续发展提供理论依据。 

研究组在研科研项目： 

1.“植物性状形成的遗传和进化基础”，中国科学院，先导B，（批准号：XDB27010202）（2018.12.03-2023.12.31），资助资金225万元，子课题负责人。

2.“毛喉素生物合成、大米食味仪和SNP芯片研制”，横向项目，（合同编号：2022110043002535）(2022.3.23-2024.12.31)，资助资金300万元，项目负责人。

3.“吉林地区水稻轻简化栽培的专用优质品种培育及技术集成”，院地合作项目，（项目编码：2021SYHZ0035）(2021.12.21-2022.12.31)，资助资金21万元, 项目负责人。

4.“木质素调控相关基因的基因功能以及代谢组学研究”，横向项目，(2022.9.14-2024.11.25)，资助资金53万元，项目负责人。

5.“植物三萜代谢多样性的催化机制及功能研究”，自然科学基金（国际合作），（批准号：3191001081）(2020.1.1-2024.12.31)，资助资金242万元，项目负责人。

6.“糖基转移酶OsUGT702A1调控水稻湿度敏感型雄性不育的分子机制及应用”，青年科学基金项目，（批准号：32101769）（2021.11.08-2024.12.31），资助资金30万元，项目负责人。

7.“水稻等作物湿敏不育技术体系与不育系创制”，重点研发项目，（批准号：2022YFF1003504-005）（2022.12.1-2027.11.30）, 资助资金60万元，子课题负责人。

8.“水稻湿敏不育分子机理”，重点研发项目，（批准号：2022YFF1003502-004）（2022.12.1-2027.11.30），资助资金70万元，子课题负责人。

9. “燕麦基因组编辑与新材料创制”，先导A类，（批准号：XDA26030301-2）（2020.11.01-2025.10.31），资助资金75万元，参加人。

10.“林源萜类成分代谢调控机制解析及异源合成体系构建”，重点研发项目，（批准号：2022YFD2200601）（2022.11.1-2026.10.31）,资助资金380万元，课题负责人。

研究论文（注*为通讯作者）： 

2022

Chang-Feng Guo, Xing-Chen Xiong, Huan Dong, Xiaoquan Qi*. 2022. Genome-wide investigation and transcriptional profiling of the oxidosqualene cyclase (OSC) genes in wheat (Triticum aestivum). Journal of Systematics and Evolution, 60(6):1378-1392.

Jing Wang, Yanhong Guo, Xue Yin, Xiaoning Wang, Xiaoquan Qi* & Zheyong Xue*. 2022. Diverse triterpene skeletons are derived from the expansion and divergent evolution of 2,3- oxidosqualene cyclases in plants. Crit Rev Biochem Mol Biol.,57(2):113-132.

Yuange Wang, Fei Du, Jian Wang, Ke Wang, Caihuan Tian, Xiaoquan Qi, Fei Lu, Xigang Liu, Xingguo Ye and Yuling Jiao*. 2022. Improving bread wheat yield through modulating an unselected AP2/ERF gene. Nat Plants., 8(8):930-939.

Zhong Zhang, Qianqian Shi, Bin Wang, Aimin Ma, Yongkang Wang, Qingtun Xue, Bingqi Shen, Halina Hamaila, Tang Tang, Xiaoquan Qi, Alisdair R. Fernie, Jie Luo,* and Xingang Li*. 2022. Jujube metabolome selection determined the edible properties acquired during domestication. The Plant Journal, 109, 1116–1133.

2021

Laibao Feng, Aimin Ma, Bo Song, Sibin Yu, Xiaoquan Qi*. 2021. Mapping causal genes and genetic interactions for agronomic traits using a large F2 population in rice. G3, 11(11), jkab318.

Ying Ma, Guanghong Cui*, Tong Chen, Xiaohui Ma, Ruishan Wang, Baolong Jin, Jian Yang, Liping Kang, Jinfu Tang, Changjiangsheng Lai, Yanan Wang, Yujun Zhao, Ye Shen, Wen Zeng, Reuben J. Peters , Xiaoquan Qi*, Juan Guo* & Luqi Huang*. 2021. Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza. Nat Commun., 12(1):685.

Aimin Ma and Xiaoquan Qi*. 2021. Mining plant metabolomes: Methods, applications, and perspectives. Plant Communications, 2(5):100238.

2020

Xufan Lian , Xiuli Zhang , Fei Wang , Xiaoning Wang , Zheyong Xue* , Xiaoquan Qi*. 2020. Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway of Melia toosendan. Physiologia Plantarum. 170(4):528-536.

Duan LX, Ma AM, Meng XB, Shen GA, Qi XQ*. 2020. QPMASS: A parallel peak alignment and quantification software for the analysis of large-scale gas chromatography-mass spectrometry (GC-MS)-based metabolomics datasets. Journal of Chromatography A, 1620-460999.

2019

Liu MY, Zhang CJ, Duan LX, Luan QQ, Li JL, Yang AG, Qi XQ*, Ren ZH. 2019. CsMYB60 is a key regulator of flavonols and proanthocyanidans that determine the colour of fruit spines in cucumber. Journal of Experimental Botany, 70: 69-84.

Zhang YC, Chi X, Feng LB, Wu XW, Qi XQ*. 2019. Improvement of multiplex semi-nested PCR system for screening of rare mutations by high-throughput sequencing. BioTechniques, 67(6):294-298.

Wang Yajun, Sudeep Subedi, Harmen de Viries, Pieter Doornenbal, Anton Vels, Goetz Hensel, Jochen Kumlehn, Paul A. Johnston, Xiaoquan Qi，Lkram Blilou, Rient E.Niks*, Simon G.Krattinger*. 2019. Orthologous receptor kinases quantitatively affect the host status of barley to leaf rust fungi. Nature Plants, 5:1129-1135.

Wu Hongyu, Xue Xiaodong, Qin Caihua, Xu Yi , Guo Yuyu, Li Xiang, Lv Wei, Li Qinxia, Mao Chuangxue, Li Luzhao, Zhao Suzhen, Qi Xiaoquan, An Hailong*. 2019. An Efficient System for Ds Transposon Tagging in Brachypodiurn distachyon. Plant physiology, 180(1):56-65.

2018

Xue ZY, Xu X, Zhou Y, Wang XN, Zhang YC, Liu D, Zhao BB, Duan LX, Qi XQ*. 2018. Deficiency of a triterpene pathway results in humidity-sensitive genic male sterility in rice. Nat. Commun., 9: 604.

Xue ZY, Tan ZW, Huang AC, Zhou Y, Sun JC, Wang XN, Thimmappa RB, Stephenson MJ, Osbourn A*, Qi XQ*. 2018. Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species. New Phytol., 218: 1076-1088.

2016

Duan LX, Molnár I, Snyder J, Shen GA, Qi XQ*. 2016. Discrimination and quantification of true biological signals in LC-MS-based metabolomics analysis. Molecular Plant, doi:10.1016/j.molp.2016.05.009. 

An TY, Cai YL, Zhao SZ, Zhou JH, Song B, Bux H, Qi XQ*. 2016. Brachypodium distachyonT-DNA insertion lines: a model pathosystem to study nonhost resistance to wheat stripe rust. Scientific Reports, 6: 25510. 

2015

Cui GH, Duan LX, Jin BL, Qian J, Xue ZY, Shen GA, Snyder J, Song JY, Chen SL, Huang LQ, Peters R, Qi XQ. 2015. Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza Bunge. Plant Physiology, 169: 1607-1618 

Niks R, Qi XQ, Marcel T. 2015. Quantitative resistance to biotrophic filamentous plant pathogens: Concepts, misconceptions, and mechanisms. Annual Review of Phytopathology, 53: 445-470. 

2014

Xie LX, Tan ZW, Zhou Y, Xu RB, Feng LB, Xing YZ, Qi X*. 2014. Identification and fine-mapping of quantitative trait loci for seed vigor in germination and seedling establishment in rice. Journal of Integrative Plant Biology, 56: 749-759. 

Shang Y, Ma YS, Zhou Y, Zhang HM, Duan LX, Chen HM, Zeng JG, Zhou Q, Wang SH, Gu WJ, Liu M, Ren JW, Gu XF, Zhang SP, Wang Y,Yasukawa K, Bouwmeester H, Qi XQ, Zhang ZH, Lucas W, Huang SW*. 2014. Biosynthesis, regulation, and domestication of bitterness in cucumber. Science, 346: 1084-1088. 

Chi X, Zhang YC, Xue ZY, Feng LB, Liu HQ, Wang F and Qi XQ*. 2014. Discovery of rare mutations in extensively pooled DNA samples using multiple target enrichment. Plant Biotechnology Journal, 12: 709-717. 

2013

Snyder J and Qi XQ*. 2013. BIOSYNTHESIS metal matters. Nat Chem Biol, 9: 295-296   

Sun JC, Xu X, Xue ZY, Snyder JH, Qi X*. 2013. Functional analysis of a rice oxidosqualene cyclase through total gene synthesis. Mol Plant 6: 1726-1729. 

2012

Duan LX, Chen TL, Li M, Chen M, Zhou YQ, Cui GH, Zhao AH, Jia W, Huang LQ and Qi X*. 2012. Use of metabolomics approach to characterize Chinese medicinal material Huangqi. Mol Plant, 5: 376-386 

Cao XH, Zhou JH, Gong XP, Zhao GY, Jia JZ and Qi X*. 2012. Identification and validation of a major quantitative trait locus for slow-rusting resistance to stripe rust in wheat. J Integr Plant Biol, 54: 330–344  

Xue ZY, Duan LX, Liu D, Guo J, Ge S, Dicks J, óMáille P, Osbourn A, Qi X*. 2012. Divergent evolution of oxidosqualene cyclases in plants.New Phytol, 193: 1022-1038 

Osbourn A, Papadopoulou KK, Qi X, Field B, Wegel E. 2012. Finding and analyzing plant metabolic gene clusters. Methods Enzymol, 517:113-38 

2010及以前

Wang LJ, Wang YJ, Wang Z, Marcel TC, Niks RE, Qi X*. 2010. The phenotypic expression of QTLs for partial resistance to barley leaf rust during plant development. Theor Appl Genet, 121:857-864 

Wu XD, Qi X*. 2010. Genes encoding hub and bottleneck enzymes of the Arabidopsis metabolic network preferentially retain homeologs through whole genome duplication. BMC Evol Biol, 10:145 

Mugford ST, Qi X, Bakht S, Hill L, Wegel E, Hughes RK, Papadopoulou K, Melton R, Philo M, Sainsbury F, Lomonossoff GP, Deb RA, Goss,RJM, Osbourn A. 2009. A serine carboxypeptidase-like acyltransferase is required for synthesis of antimicrobial compounds and disease resistance in oats. Plant Cell, 21: 2473-2484 

Zhao SZ, Qi X*. 2008. Signaling in plant disease resistance and symbiosis. J Integr Plant Biol, 50(7}: 799-807 

Mylona P, Owatworakit A, Papadopoulou K, Jenner H, Qin B, Findlay K, Hill L, Qi X, Bakht S, Melton R, Osbourn A. 2008. Sad3 and Sad4 are required for saponin biosynthesis and root development in oat. Plant Cell, 20(1): 201-212 

Qi X, Bakht S, Qin B, Leggett M, Hemmings A, Mellon F, Eagles J, Werck- Reichhart D, Schaller H, Lesot A, Melton R, Osbourn A. 2006. A different function for a member of an ancient and highly conserved cytochrome P450 family：From essential sterols to plant defense. Proc Natl Acad Sci USA, 103: 18848-18853 

Bakht S, Qi X*. 2005. Ligation mediated rolling-circular amplification (RCA) based approaches to SNP detection. Expert Rev Mol Diagn, 5: 111-116 

Qi X, Pittaway TS, Lindup S, Liu H, Waterman E, Padi FK, Hash CT, Zhu J, Gale MD, Devos KM. 2004. An integrated genetic map and a new set of SSR markers for pearl millet Pennisetum glaucum. Theor Appl Genet, 109: 1485-1493 

Qi X, Bakht S, Leggett M, Maxwell C, Melton R, Osbourn A. 2004. Clustered genes for secondary metabolism in oat-Implications for the evolution of metabolic diversity in plants. Proc Natl Acad Sci USA, 101: 8233-8238 

Osbourn AE, Qi X, Townsend B, Qin B. 2003. Dissecting plant secondary metabolism – constitutive chemical defenses in cereals. New Phytol, 159: 101-108 

Haralampidis K, Bryan G, Qi X, Papadopoulou K, Bakht S, Melton R, Osbourn A. 2001. A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots. Proc Natl Acad Sci USA, 98: 13431-13436 

Qi X*, Bakht S, Devos KM, Gale MD, Osbourn A. 2001. L-RCA (ligation-rolling circle amplification): a general method for genotyping of single nucleotide polymorphisms (SNPs). Nucleic Acid Res, 29: e116 

Qi X*, Lindup S, Pittaway TS, Allouis S, Gale MD, Devos KM. 2001. Development of simple sequence repeat (SSR) markers from bacterial artificial chromosomes (BACs) without sub-cloning. BioTechniques, 31: 355-362 

Allouis S, Qi X, Lindup S, Gale MD, Devos KM. 2001. Construction of a pearl millet BAC library using pBAC/SACB1，a positive selection vector．Theor Appl Genet, 102: 1200-1205 

Qi X*, Fufa F, Sijtsma D, Niks RE, Lindhout P, Stam P. 2000. The evidence for abundance of QTLs for partial resistance to Puccinia hordei on the barley genome. Mol Breed, 6: 1-9 

Qi X*, Jiang GL, Chen WQ, Niks RE, Stam P, Lindhout P. 1999. Isolate-specific QTLs for partial resistance to Puccinia hordei in barley. Theor Appl Genet, 99: 877-884 

Qi X*, Niks RE, Stam P, Lindhout P. 1998. Identification of QTLs for partial resistance to leaf rust (Puccinia hordei) in barley. Theor Appl Genet, 96: 1205-1215 

Qi X*, Stam P, Lindhout P. 1998. Use of locus-specific AFLP markers to construct a high-density molecular map in barley. Theor Appl Genet, 96: 376-384 

Schut JW, Qi X, Stam P. 1997. Relationship between AFLP based genetic similarities and coefficients of co-ancestry in barley．Theor Appl Genet ,95: 1161-1168 

Qi X*, Lindhout P. 1997. Development of AFLP markers in barley．Mol Gen Genet, 254: 330-336 

Qi X*, Stam P, Lindhout P. 1996. Comparison and integration of four barley genetic maps. Genome, 39: 379-394 

著作专著： 

[1]  漆小泉，王玉兰，陈晓亚主编，2011。植物代谢组学－方法与应用。北京：化学工业出版社。（中文） 

专利： 

[1]  漆小泉，薛哲勇，段礼新. 帕克醇合成相关蛋白及其编码基因与应用: 中国, ZL200810117225.X. 2011-03-30.  

[2] 漆小泉，薛哲勇，段礼新. 异山柑子萜醇合成相关蛋白及其编码基因与应用: 中国, ZL200810117226.4. 2011-04-20. 

[3] 漆小泉，薛哲勇，刘丹，段礼新. 一种新的三萜合成酶的功能及应用；中国，ZL2011102479987.7. 2013-08-14 

[4] 漆小泉，曹晓花. 一种多重检测基因组DNA多态性的方法及其专用探针；中国，ZL201110121242.2. 2013-10-23. 

[5] 薛哲勇，漆小泉，孙俊聪，段礼新. 一种优化三萜合酶编码基因及其应用；中国，ZL201310002085.2. 2014-03-26 .

[6] 漆小泉，崔光红，靳保龙. SmCPS4蛋白及其编码基因与应用；中国，ZL201410085600.2. 2016-03-02.( 已转让)

[7] 漆小泉，王亚军. 大麦抗叶锈病蛋白及其编码基因与应用；中国，ZL201510312223.6. 2019-01-08.(已转让)

[8] 漆小泉，赵素珍. 一种检测SNP的方法；中国，ZL201410778560.X. 2019-06-11. (已转让)

[9] 漆小泉，池旭，张英春. 一种用于新一代测序分析的多重目的DNA片段富集方法；中国，ZL201210253791.X. 2016-3-30. (已转让)

[10] 漆小泉，段礼新. 一种区分假阳性质谱峰信号且定量校正质谱峰面积的代谢组学方法；中国，ZL201610346054.2. 2018-06-01.

[11] 漆小泉, 薛哲勇, 张英春, 徐霞, 刘丹. 一种制备育性减低植物的方法；中国，ZL201710802863.4. 2020-05-15.

[12] 漆小泉, 薛哲勇, 张英春, 徐霞, 刘丹. 一种制备育性减低植物的方法；中国，ZL201280006361.6. 2017-10-10.(已转让)

[13] 漆小泉，谭政委，薛哲勇. 水稻鞘醇合成相关蛋白及其编码基因与应用；中国，ZL201610509844.8. 2019-08-20.

[14] 漆小泉，张英春，池旭，段礼新. 利用多重PCR富集目标DNA片段的方法. 中国，ZL201910379847.8. 2021-01-15.

[15] 漆小泉，张英春，冯来宝，池旭. 一种多重PCR方法. 中国，ZL201910380299.0. 2021-01-15.

[16] 漆小泉，张英春，冯来宝，池旭. 一种筛选水稻目的基因突变体的方法. 中国，ZL201910379866.0. 2020-12-08.

[17] 漆小泉，孙俊聪，薛哲勇. 一种与木栓酮合成相关的基因及其应用. 中国，ZL201711339630.1. 2021-04-13.

[18] 漆小泉，周媛，薛哲勇. 一种制备水稻湿度敏感型雄性不育材料的方法及相关基因. 中国，ZL201710403388.3. 2020-04-14.(已转让)

[19] 漆小泉，马爱民，宋波.  Os07g0503900蛋白在调控植物对杂草抗性中的应用. 中国，ZL202010169781.2.（已转让）

[20] 漆小泉，马爱民，宋波. 麦黄酮-5-O-葡萄糖糖苷在调控植物对杂草抗性中的应用. 中国， ZL202010169977.1.（已转让）