2008年在西北农林科技大学获学士学位，2012年在中国科学院遗传与发育生物学研究所获硕士学位，2012年到2017年在德国植物遗传和作物研究所（IPK，Leibniz Institute of Plant Genetics and Crop Plant Research）从事博士研究工作（获得德国哈勒-维滕贝格大学博士学位）。2017年到2018年分别在德国植物遗传和作物研究所和剑桥大学Sainsbury实验室从事博士后研究。现任中国科学院植物研究所植物器官发生的分子调控研究组组长。

主要研究工作：

主要以小麦和燕麦为材料，综合利用分子生物学、细胞生物学、遗传学和生物化学等技术手段，结合基因组、转录组和代谢组等多组学数据分析，开展作物高产和耐逆的分子机理研究。主要研究方向：（1）麦类作物穗部器官发生、发育和退化的分子调控机理研究；（2）麦类作物穗型的分子调控机理研究；（3）麦类作物环境适应性的分子模块解析。

主持和参加的科研项目：

[1] “高蛋白高油植物挖掘利用及大豆减替应用” （2024.11-2029.10），中国科学院先导专项（B类），课题负责人

[2] “HGY1基因调控小麦籽粒数目的分子机理解析” （2023.1-2026.12），国家自然科学基金面上项目，项目负责人

[3] “小麦产量性状的分子基础” （2019.11-2024.10）， 中国科学院先导专项（A类），任务负责人

[4] 中国科学院人才计划，中国科学院项目（2019.1-2023.12），主持人

研究论文（注*为通讯作者）：

2025

Liu YY, Zhang LL, Zhu AT, Shen LP, Zhang JQ, Chen J, Chang GW, Yin CB, Wang ZY, Sun ZW, Shen KC, Xu XW, Sun MJ, Xin MM, Wu JH, Lu ZF, Tong YP, He ZH, Lu F*, Hao YF*, Chen W*, Guo ZF*. 2025. Multi-omics identifies key genetic and metabolic networks regulating spike organ development in wheat. The Plant Cell,doi:10.1093/plcell/koaf250.

Shen KC, Ye BT, Yu XC, Shen P, Yu R, Yin CB, Xu XW, Dong J, Wang ZY, Wu H, Zang YM, Li JX, Peng YC, Han DJ, He ZH, Zhang XY, Li JM, Hao CY, Zhang ZL, Kang LP, Xu S, Lu F*, Hao YF*, Wu TT*, Wu JH*, Guo ZF*. 2025. Dissection of genomic drivers of spike morphology changes in wheat by high-throughput phenotyping. Cell Reports, 44: 116120.

Shen LP, Qi XL, Guo ZF*. 2025. Wheat. Current Biology, 35: R1037-R1043.

Shen LP, Sun ZW, Liu YY, Shen KC, Wang ZM, Ye BT, Wang ZY, Guo ZF*. 2025. Genetic regulation differences of VRS genes in the development of lateral spikelets in two-rowed barley. Plant, Cell & Environment, 48: 8947-8959.

2024

Liu YY, Yu R, Shen LP, Sun MJ, Peng YC, Zeng QD, Shen KC, Yu XC, Wu H, Ye BT, Wang ZY, Sun ZW, Liu DN, Sun XH, Zhang ZL, Dong JY, Dong J, Han DJ, He ZH, Hao YF*, Wu JH*, Guo ZF*. 2024. Genomic insights into the modifications of spike morphology traits during wheat breeding. Plant, Cell & Environment, 47: 5470-5482.

 Shen LP, Zhang LL, Yin CB, Xu XW, Liu YY, Shen KC, Wu H, Sun ZW, Wang K, He ZH, Zhang XY, Hao CY, Hou J, Bi AY, Zhao XB, Xu DX, Ye BT, Yu XC, Wang ZY, Liu DN, Hao YF*, Lu F*, Guo ZF*. 2024. The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike. The Crop Journal, 12:1

Ye BT, Liu YY, Wang ZY, Shen LP, Yin CB, Shen KC, Sun JQ, Xu XW, Sun MJ, Wu JH, He ZH, Yu XC, Lu F*, Hao YF*, Guo ZF*. 2024. Genetic basis of geographical differentiation, breeding selection, domestication effects and breeding application for TaJAZ1 in wheat. Journal of Genetics and Genomics, 51:665-668

2023

Liu YY, Shen KC, Yin CB, Xu XW, Yu XC, Ye BT, Sun ZW, Dong JY, Bi AY, Zhao XB, Xu DX, He ZH, Zhang XY, Hao CY, Wu JH, Wang ZY, Wu H, Liu DN, Zhang LL, Shen LP, Hao YF*, Lu F*, Guo ZF*. 2023. Genetic basis of geographical differentiation and breeding selection for wheat plant architecture traits. Genome Biology, 24:114

Liu YY, Chen J, Yin CB, Wang ZY, Wu H, Shen KC, Zhang ZL, Kang LP, Xu S, Bi AY, Zhao XB, Xu DX, He ZH, Zhang XY, Hao CY, Wu JH, Gong Y, Yu XC, Sun ZW, Ye BT, Liu DN, Zhang LL, Shen LP, Hao YF*, Ma YZ*, Lu F*, Guo ZF*. 2023.  A high‑resolution genotype–phenotype map identifies the TaSPL17 controlling grain number and size in wheat. Genome Biology, 24:196

Shen LP, Liu YY, Zhang LL, Sun ZW, Wang ZY, Jiao YN, Shen KC, Guo ZF*. 2023. A transcriptional atlas identifies key regulators and networks for the development of spike tissues in barley. Cell Reports, 42: 113441

2022

Xiao J*, Liu B, Yao Y, Guo Z, Jia H, Kong L, Zhang A, Ma W, Ni Z, Xu S, Lu F, Jiao Y, Yang W, Lin X, Sun S, Lu Z, Gao L, Zhao G, Cao S, Chen Q, Zhang K, Wang M, Wang M, Hu Z, Guo W, Li G, Ma X, Li J, Han F, Fu X, Ma Z, Wang DW*, Zhang XY*, Ling HQ*, Xia GM*, Tong YP*, Liu ZY*, He ZH*, Jia JZ*, Chong K*. 2022. Wheat genomic study for genetic improvement of traits in China. Sci China Life Sci, 65:1718-1775.

2018以前

Guo ZF*, Liu GZ, Zhao YS, Reif JC, Roeder MS, Ganal MW, Schnurbusch T*. 2018. Genome-wide association analysis of plant growth traits during the stem elongation phase in wheat. Plant Biotechnology Journal, 16: 2042-2052

Guo ZF*, Chen DJ, Roeder MS, Ganal MW, Schnurbusch T*. 2018. Genetic dissection of pre-anthesis sub-phase durations during the reproductive spike development of wheat. Plant Journal, 95: 909–918

Guo ZF, Zhao YS, Reif JC, Roeder MS, Ganal MW, Schnurbusch T*. 2018. Manipulation and prediction of spike morphology traits for the improvement of grain yield in wheat. Scientific Reports, 8: 14435

Guo ZF, Chen DJ, Schnurbusch T*. 2018. Plant and floret growth at distinct developmental stages during the stem elongation phase in wheat. Frontiers in Plant science, 9:330

Guo ZF, Chen DJ, Alqudah AM, Roeder MS,  Ganal MW, Schnurbusch T*. 2017 Genome-wide association analyses of 54 traits identified multiple loci for the determination of floret fertility in wheat. New Phytologist, 214: 257-270

Guo ZF, Slafer GA, Schnurbusch T*. 2016. Genotypic variation in spike fertility traits and ovary size as determinants of floret and grain survival rate in wheat. Journal of Experimental Botany, 67: 4221-4230

Guo ZF, Schnurbusch T*. 2016. Costs and benefits of awns. Journal of Experimental Botany, 67: 2533-2535

Guo ZF, Schnurbusch T*. 2015. Variation of floret and spikelet fertility in wheat revealed by tiller removal. Journal of Experimental Botany, 66: 5945-5958

Guo ZF, Chen DJ, Schnurbusch T*. 2015. Variance components, heritability and correlation analysis of anther and ovary size during the floral development of bread wheat. Journal of Experimental Botany, 66:3099-3111

专利： 

[1] 郭自峰、申立平、刘洋洋、孙祉文、王梓颖、叶波涛、沈阔程、吴贺、张丽丽。大麦不同单倍型在检测大麦产量性状中应用。中国，授权公告日：2022-05-17，专利号：ZL202110600143.6